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| Diastereoselective α-Alkylation of β-Amino Esters: Preparation of Novel α-Substituted β-Amino Esters from α-Amino Acids | |
| 作者姓名： | Zhi Hua MA Cong LIU Yong Hua ZHAO Wei LI Jian Bo WANG* Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education |
| 作者单位： | Zhi Hua MA，Cong LIU，Yong Hua ZHAO，Wei LI，Jian Bo WANG* Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education，Department of Chemical Biology，College of Chemistry，Peking University，Beijing 100871 |
| 基金项目： | The project is generously supported by the National Natural Science Foundation of China (Grant No. 29972002，20172002)，the Trans-Century Training Programme Foundation for the Talents by Ministry of Education，and Bayer Co. Ltd (Germany). We thank Dr |
| 摘 要： | b-Amino acids and their derivatives have attracted considerable attention in recent years due to their occurrence in biologically active natural products, such as dolastatins 11, cyclohexylnorstatine 22 and taxol 33. bAmino acids also find application in the synthesis of blactams4, piperidines5, indolizidines6. Moreover, the peptides consisting of bamino acids, the so called bpeptides, have been extensively studied recently7. Consequently, considerable efforts have been directed to the synt… |
| 关 键 词： | β-amino esters |
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