| Synthesis and Crystal Structure of Cis 2-（6-Chloro-3-pyridylmethylamino）-4-chlorophenyl- 5,5-dimethyl- 1,3,2-dioxaphosphinane 2-Oxides |
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| 引用本文： | 刘漪,魏佳,石德清,王成刚.Synthesis and Crystal Structure of Cis 2-（6-Chloro-3-pyridylmethylamino）-4-chlorophenyl- 5,5-dimethyl- 1,3,2-dioxaphosphinane 2-Oxides[J].结构化学,2005,24(2):196-200. |
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| 作者姓名： | 刘漪 魏佳 石德清 王成刚 |
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| 作者单位： | College of Chemistry，Central China Normal University，Key Laboratory of Pesticide and Chemical Biology，Ministry of Education of China，Wuhan 430079，China |
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| 基金项目： | The project was supported by NNSFC (20302002) |
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| 摘 要： | 1 INTRODUCTION Neonicotinioid insecticides as nicotinic acetyl-choline receptor inhibitors have attracted increasingattention because of its safety, low toxicity, wide andhigh activities1, . A lot of new insecticides such as 2]imidacloprid, acetamiprd and nitenpyram have beencommercialized. It is found that most biologicallyactive nicotinic compounds contain 3-aminomethyl-pyridine moiety3]. Due to their wide biological acti-vities, organic phosphorus heterocyclic compoundsplay an import…
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| 关 键 词： | 晶体结构 有机磷杀虫剂 合成方法 X射线分析技术 |
Synthesis and Crystal Structure of Cis 2-(6- Chloro-3-pyridylmethylamino)-4-chlorophenyl-5,5-dimethyl-1,3,2-dioxaphosphinane 2-Oxides |
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| Abstract: | The crystal structure of the title compound (C17H19Cl2N2O3P, Mr= 401.21) has
been determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/n
with a = 6.1648(6), b = 19.943(2), c = 15.268(2) (A),β = 99.220(2)°, V = 1852.8(3) (A)3, Z = 4, Dc =
1.438 g/cm3, F(000) = 832,μ(MoKa) = 0.456 mm-1, the final R = 0.0622 and wR = 0.1586 for 3986
observed reflections (I ＞ 2σ(I)). X-ray analysis reveals that the product is a thermodynamically stable cis isomer. The intramolecular hydrogen bond N(2)-H(2A)…O(1) is observed in the title compound. |
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| Keywords: | crystal structure synthesis stereo-configuration organic phosphorus insecticide |
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