pluronics和卵磷脂混合载药乳化膜的稳定性

单滴法;pluronics;卵磷脂;混合界面吸附膜;乳状液稳定性

Stability of Drug-carrying Mixed Emulsion Film Formed from Pluronics and Lecithin

The stabilities of the adsorption films of the o/w emulsions were investigated with a home made drop stability apparatus in which isopropyl myristate(IPM) was used as the oil and Pluronic copolymers(L61,L64,F68 and F108),lecithin(PC) and their mixture were used as the emulsifier,respectively.The results show that Pluronic molecule with a long PEO block benefited the stabilization of the film.When single Pluronic copolymer was used as the emulsifier,however,the limited length of the PPO blocks restricted their bending to insert the oil drop,resulting in the reduction of the compactness of the molecules arranging at the oil/water interface because of the repulsion between the long PEO blocks.The addition of PC improved the arrangement of the emulsifier molecules at the oil/water interface and promoted them to pack tightly.Thus the long PEO blocks wrapped on the surface of oil drop stabilized the oil-drops in water.The present work has demonstrated that the mixed emulsifiers of F68 PC or F108 PC with 0.012 5 g/mL Pluronics and 0.016 7 g/mL PC can form a stable adsorption film at the oil/water interface.