Synthesis and anticancer property of one Ce(III) compound based on 5-(2-pyrazinyl)tetrazole-2-acetic acid |
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| Authors: | Duo Xu Xin Yu Hao Yu Jie Shi Zhi Kang Wang Yan Li Wan Ting Su |
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| Affiliation: | Jiangsu Laboratory of Advanced Functional Material, Department of Chemistry and Material Engineering, Changshu Institute of Technology, Changshu, P.R. China |
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| Abstract: | ![]()
Mononuclear [Ce(pztza)2(H2O)6](pztza)·H2O (1) (pztza = 5-(2-pyrazinyl)tetrazole-2-acetato) has been prepared and characterized by IR, elemental analysis and single-crystal X-ray diffraction. PEG-5000 (poly(ethyleneglycol-5000)) coated [Ce(pztza)2(H2O)6](pztza)·H2O nanoparticles (NPs) can disperse into distilled water. In vitro study on Hela cells shows that Hpztza is nontoxic while [Ce(pztza)2(H2O)6](pztza)·H2O NPs show high toxicity with half-maximal inhibitory concentration (IC50) of 17 μg/mL (1.93 × 10?5 M). In addition, such NPs can inhibit the migration of Hela cells effectively. |
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| Keywords: | Ce(III) 5-(2-Pyrazinyl)tetrazole-2-acetic acid Hela In vitro |
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