液相色谱-串联质谱法测定小型家用电器塑料部件中双酚A

建立了小型家用电器塑料部件中双酚A的液相色谱-串联质谱(LC-MS/MS)检测方法。采用快速溶剂萃取仪对样品进行萃取,以Sep-Pak C18固相萃取柱净化,甲醇-水(含有0.05%氨水)混合液作为流动相,负离子模式下进行MS/MS检测。结果表明: 该方法在5～100 μg/L范围内线性关系良好,相关系数(r2)为0.9991。在10、25和75 μg/kg 3个添加水平下,双酚A的平均回收率为95.2%～109.7%,相对标准偏差均小于3.8%,检出限为10 μg/kg。该方法操作简便,灵敏度高,适用于家用电器塑料部件中双酚A的残留分析。

Determination of bisphenol A in plastic parts of small household appliances by liquid chromatography-tandem mass spectrometry

A method for the determination of bisphenol A in the plastic parts of small household appliances by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed. The sample was extracted with accelerated solvent extraction (ASE) and purified by Sep-Pak C18 solid phase extraction. Bisphenol A was separated and detected using LC-MS/MS in negative ion mode with the mobile phases of methanol and water (containing 0.05% ammonia water). The linearity of the method was good in the range of 5 μg/L to 100 μg/L. The recoveries for the spiked sample were from 95.2% to 109.7% at the three levels, 10, 25 and 75 μg/kg. The relative standard deviations were less than 3.8%. The limit of detection was 10 μg/kg. The method is easy-handling, time-saving, sensitive and suitable for the determination of the residual bisphenol A in the plastic parts of household appliances.