Total synthesis of (-)-reveromycin a |
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| Authors: | El Sous Mariana Ganame Danny Tregloan Peter A Rizzacasa Mark A |
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| Institution: | School of Chemistry, The University of Melbourne, Victoria 3010, Australia. |
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| Abstract: | The asymmetric total synthesis of (-)-reveromycin A is described. The key steps involved a Lewis acid catalyzed inverse electron demand hetero-Diels-Alder reaction followed by hydroboration/oxidation to afford the spiroketal core 4 in a highly stereoselective manner and introduction of the C18 hemisuccinate by high-pressure acylation. |
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