Biodegradable Passion Fruit‐Like Nano‐Architectures as Carriers for Cisplatin Prodrug |
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Authors: | Domenico Cassano Melissa Santi Valentina Cappello Stefano Luin Giovanni Signore Valerio Voliani |
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Institution: | 1. Center for Nanotechnology Innovation @NEST, Istituto Italiano di Tecnologia, P.zza San Silvestro, Pisa, PI, Italy;2. NEST, Scuola Normale Superiore, P.zza San Silvestro, Pisa, PI, Italy;3. NEST, Istituto Nanoscienze‐CNR, P.zza San Silvestro, Pisa, PI, Italy |
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Abstract: | Accumulation of inorganic nanostructures in the excretory system organs increases their likelihood of toxicity and interference with common medical diagnoses. Thus, one of the major concerns regarding their clinical translation is related to their persistence in organisms. Here the authors demonstrate that nano‐architectures composed by hollow silica nanocapsules embedding arrays of ultrasmall gold nanoparticles undergo biodegradation in cellular environment affording small, potentially clearable building blocks. Furthermore, the authors present their exploitation in glutathione‐triggered release of covalently loaded cisplatin prodrug. This endogenously triggered release leads to high cytotoxicity to human pancreatic carcinoma cells, setting the way for promising applications to synergistic dual chemo/radio‐therapy and radio‐imaging. |
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Keywords: | biodegradation cisplatin gold nanoparticle hollow silica human pancreatic carcinoma |
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