Bio-safety assessment of carbon quantum dots,N-doped and folic acid modified carbon quantum dots: A systemic comparison |
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| Institution: | 1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;2. West China School of Stomatology, Sichuan University, Chengdu 610041, China;3. West China School of Public Health and Healthy Food Evaluation Research Center, Sichuan University, Chengdu 610041, China;1. College of Materials Science and Engineering Laboratory of Fiber Materials and Modern Textile, The Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, PR China;2. Collaborative Innovation Center for Marine Biomass Fibers, Materials and Textiles of Shandong Province, Qingdao University, Qingdao 266071, PR China;1. Department of Chemistry, The City College of New York, New York, NY, 10031, USA;2. Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, NY, 10016, USA;3. Department of Inorganic Chemistry, Faculty of Science, The University of Malaga, Campus de Teatinos, 29071, Málaga, Spain;4. Madeira Chemistry Research Centre-CQM, University of Madeira, Campus de Penteada, 9020-105 Funchal, Portugal;5. Department of Microbiology, Faculty of Science, The University of Malaga, 29071, Málaga, Spain;1. Department of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan;2. Department of Chemistry, National Taiwan University, Taipei, Taiwan;3. Center of Excellence for the Oceans, National Taiwan Ocean University, Keelung, Taiwan;4. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan;1. Jiangsu Collaborative Innovation Center for Biological Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China;2. Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing 210023, China;3. Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China;4. Nanjing Zhou Ninglin Advanced Materials Technology Company Limited, Nanjing 211505, China;1. Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, PR China;2. Liquor Making Biology Technology and Application of Key Laboratory of Sichuan Province, College of Bioengineering, Sichuan University of Science and Engineering, Zigong, 643000, PR China;1. College of Chemistry, Liaoning University, Shenyang 110036, PR China;2. Department of Chemistry, Baotou Teachers’ College, Baotou 014030, PR China |
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| Abstract: | The carbon quantum dots(CQDs) and their functionalized materials are promising in biomedical field because of their unique properties;meanwhile,a growing concern has been raised about the potential toxicity of these modified materials in biosystem.In this study,we synthesized original CQDs and two common functionalized CQDs including N-doped CQDs(NCQDs) and folic acid-modified CQDs(FACQDs),and compared the toxicity and biocompatibility with each other in vitro and in vivo.L929,C6 and normal cell MDCK were selected to detect the adverse reaction of these materials in vitro.No acute toxicity or obvious changes were noted from in vitro cytotoxicity studies with the dose of these CQD materials increasing to a high concentration at 1 mg/mL.Among these materials,the FA-CQDs show a much lower toxicity.Moreover,in vivo toxicity studies were performed on the nude mice for 15 days.The experimental animals in 10 or 15 mg/kg groups were similar with animals treated by phosphate buffer solution(PBS) after 15 days.The results of the multifa rious biochemical parameters also suggest that the functionalized products of CQDs do not influence the biological indicators at feasible concentration.Our findings in vitro and in vivo through toxicity tests demonstrate that CQDs and their modified materials are safe for future biological applications. |
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| Keywords: | Carbon quantum dots (CQDs) Functional materials Biocompatibility Fluorescence bioimaging Biodistribution |
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