Synthesis of highly substituted 2,3-dihydro-1H-pyrrole derivatives via a tandem regioselective addition of nitrones to 1,3-enynes with subsequent rearrangement |
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| Authors: | Saravanan Sivaperuman Azath Ismail Abulkalam Muthusubramanian Shanmugam |
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| Institution: | Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, India. |
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| Abstract: | A novel method for the synthesis of 1,3-enynes is described through oxidative cyclization of the semicarbazones of Michael adducts having potential nitrile functionality. Reaction of these 1,3-enynes with diaryl nitrones has yielded a diastereomeric mixture of highly substituted 2,3-dihydro-1H-pyrrole derivatives via a tandem regioselective addition with subsequent rearrangement. |
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