Metal-free, organocatalytic cascade formation of C-N and C-O bonds through dual sp3 C-H activation: oxidative synthesis of oxazole derivatives |
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| Authors: | Xie Jin Jiang Honglai Cheng Yixiang Zhu Chengjian |
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| Affiliation: | State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China. |
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| Abstract: | An organocatalytic cascade reaction that involves the formation of C-N, C-O and C=N bonds in one process via dual sp(3) C-H activation has been developed. This protocol affords a facile metal-free methodology for the synthesis of oxazole derivatives in air under mild conditions. |
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