首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Microwave-assisted synthesis of 5-aryl-3-hydroxy-2-oxindole derivatives and evaluation of their antiglaucomic activity
Institution:1. Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;2. Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation;3. Volgograd State Medical University, 400087 Volgograd, Russian Federation;4. Helmholtz National Medical Centre of Eye Diseases, 105062 Moscow, Russian Federation;1. Department of Materials Science, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;2. Department of Chemistry, M. V. Lomonosov Moscow State University, 119991 Moscow, Russian Federation;1. Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634050 Tomsk, Russian Federation;2. Siberian State Medical University, 634050 Tomsk, Russian Federation;3. National Research Tomsk Polytechnic University, 634050 Tomsk, Russian Federation;4. Scientific Center for Mental Health, 115522 Moscow, Russian Federation;5. E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, 634028 Tomsk, Russian Federation;1. D. I. Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russian Federation;2. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119334 Moscow, Russian Federation;1. A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 664033 Irkutsk, Russian Federation;2. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russian Federation
Abstract:A set of new 5-aryl-3-hydroxy-2-oxindoles was synthesized by decarboxylative condensation of the corresponding 5-aryl-substituted isatins with malonic or cyanoacetic acids under microwave irradiation. The antiglaucomic activity of the obtained compounds was evaluated. The most water soluble compounds can reduce the intraocular pressure (IOP) up to 2 Torr.
Keywords:oxindole  indolin-2-one  NRH:quinone oxidoreductase 2 inhibitors  intraocular pressure  antiglaucomic  microwave irradiation  condensation
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号