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Effect of Deacetylation on Statmhokinetic Activity of Colchicine Derivatives |
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| Authors: | Z. M. Enikeeva D. Sh. Nurullaeva N. N. Kuznetsova Z. S. Khashimova |
| Affiliation: | (1) Republic Oncology Scientific Center, Ministry of Health, Republic of Uzbekistan, Tashkent;(2) A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent |
| Abstract: | Screening of colchicine derivatives that was carried out with the tumor culture CaPa in a cytotoxicity test showed that deacetylation decreases the cytotoxicity and increases the mitotic index. Lower toxicity of the deacetylated colchicine derivatives was also noted. |
| Keywords: | alkaloids colchicine colchicine derivatives cell culture statmhokinetic and mitotic activity |
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