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Investigation of gold-coated bare fiber probe for in situ intra-vitreous coherence domain optical imaging and sensing |
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| Authors: | J-H Han I K Ilev D-H Kim C G Song J U Kang |
| Institution: | 1. Department of Electrical and Computer Engineering, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD, 21218, USA 2. Center for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA 3. School of Electronics & Information Engineering, Center for Advanced Image and Information Technology, Chonbuk National University, 664-14 1-Ga Deokjin-dong, Jeonju, Jeonbuk, 561-756, South Korea |
| Abstract: | We have investigated the usage of gold-plated bare fiber probes for in situ imaging of retinal layers and surrounding ocular tissues using time-domain common-path optical coherence tomography. The fabricated intra-vitreous gold-plated micro-fiber probe can be fully integrated with surgical tools working in close proximity to the tissue to provide subsurface images having a self-contained reference plane independent to the Fresnel reflection between the distal end of the probe and the following medium for achieving reference in typical common-path optical coherence tomography. We have fully characterized the probe in an aqueous medium equivalent to the vitreous humor in the eye and were able to differentiate various functional retinal tissue layers whose thickness is larger than the system’s resolution. |
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