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| 高效液相色谱法测定环境水中超痕量双酚A | |
| 引用本文： | 江明,林怡,张江华,梅素容,周宜开,吕斌. 高效液相色谱法测定环境水中超痕量双酚A[J]. 分析化学, 2006, 34(10): 1419-1422 |
| 作者姓名： | 江明 林怡 张江华 梅素容 周宜开 吕斌 |
| 作者单位： | 华中科技大学同济医学院公共卫生学院环境与健康教育部重点实验室,武汉,430030;华中科技大学同济医学院药学院,武汉,430030;华中科技大学同济医学院药学院,武汉,430030;华中科技大学同济医学院公共卫生学院环境与健康教育部重点实验室,武汉,430030 |
| 基金项目： | 国家自然科学基金资助课题(No.30200061,20477013) |
| 摘 要： | 合成单分散双酚A(BPA)分子印迹微球并以其为高效液相色谱柱填充材料,建立了一种大体积直接进样HPLC法测定环境水中超痕量BPA的方法。方法的检出限(LOD)和测定限(LOQ)分别为0.03nmol/L和0.1nmol/L;在0.1~100nmol/L范围内具有良好的线性(r2=0.9983)。本方法用于表层湖水中BPA的检测,实际样品的加标回收率在99%~101.4%间;相对标准偏差(RSD%)低于8.1%(n=5)。 |
| 关 键 词： | 分子印迹聚合物 大体积直接进样 双酚A 高效液相色谱法 |
| 收稿时间： | 2006-02-23 |
| 修稿时间： | 2006-02-232006-05-26 |
Determination of Ultra-trace Bisphenol A in Water Samples by Chromatography with Large Volume Direct Injection |
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| Abstract: | A method was developed for the determination of ultra-trace bisphenol A (BPA) in water sample by chromatography with large volume (40 mL) direct injection without pretreatment. The enrichment and separation of BPA in water were achieved on a BPA imprinted polymer microspheres packed in a high performance liquid chromatography column. The calibration graph was linear with R~ 2 >0.998 in the ranges of 0.1-100 nmol/L BPA standard solution. The limit of detection and limit of quantitation were 0.03 nmol/L and 0.1 nmol/L, respectively. For spiked lake water analysis, the RSD (N=5) was less than 8.1% and the recoveries were 96%-101.4%. |
| Keywords: | Molecular imprinted polymer large volume direct injection bisphenol A high performance liquid chromatography |
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