Catalytic asymmetric nitroaldol (Henry) reaction with a zinc-Fam catalyst |
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Authors: | Bulut Adnan Aslan Ayhan Dogan Ozdemir |
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Institution: | Department of Chemistry, Kirikkale University, 71450, Kirikkale, Turkey |
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Abstract: | Ferrocenyl-substituted aziridinylmethanol (Fam-1) was used as a catalyst with zinc for the asymmetric nitroaldol (Henry) reaction. This catalyst worked with a variety of aldehydes (aromatic, aliphatic, alpha,beta-unsaturated, and heteroaromatic) and alpha-ketoesters to give the nitroaldol product in up to 97% yield and 91% ee. The chiral ligand can be recovered and recycled without losing its activity. |
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