|
|||||
|
|
| 硒化壳聚糖诱导NB4细胞凋亡及周期阻断作用 | |
| 引用本文： | 邓守恒,孙各琴,邓守明,毛达勇. 硒化壳聚糖诱导NB4细胞凋亡及周期阻断作用[J]. 广东微量元素科学, 2006, 13(5): 11-13 |
| 作者姓名： | 邓守恒 孙各琴 邓守明 毛达勇 |
| 作者单位： | 1. 郧阳医学院生化教研室,湖北,十堰,442000 2. 丹江口市第一医院,湖北,丹江口,442700 |
| 摘 要： | 为研究硒化壳聚糖对NB4细胞的凋亡及周期阻断作用,用流式细胞法观察了药物对细胞的诱导凋亡及周期阻断作用。结果表明,硒化壳聚糖作用NB4细胞24 h,可剂量依赖性地诱导细胞凋亡并使G0—G1期细胞增多。提示硒化壳聚糖可诱导细胞凋亡,并对NB4细胞周期有特异性阻断作用。 |
| 关 键 词： | 硒化壳聚糖 细胞凋亡 细胞周期 |
| 文章编号： | 1006-446X（2006）05-0011-03 |
| 收稿时间： | 2006-02-21 |
| 修稿时间： | 2006-02-21 |
The Cell Cycle Block and Inducing Apoptosis Effect of Selenium Chitosan on NB4 Cells |
|
| DENG Shouheng,SUN Geqing,DENG Shouming,Mao Dayong. The Cell Cycle Block and Inducing Apoptosis Effect of Selenium Chitosan on NB4 Cells[J]. Trace Elements Science, 2006, 13(5): 11-13 | |
| Authors: | DENG Shouheng SUN Geqing DENG Shouming Mao Dayong |
| Abstract: | To study the cell cycle block and inducing apoptosis effect of selenium chitosan on NB4 cells, the cell cycle block effect and inducing apoptosis effect were observed by using flow cytometry. The results showed that exposure of NB4 cells to 50 - 100 mg/L of selenium chitosan for 24 h produced a dose dependent inerease in G0--G1 phase cells and an increase in apoptotic rate. It concluded selenium chitosan could block NB4 ceils in G0--G1 phase and induce apoptosis in a dose dependent manner. |
| Keywords: | selenium chitosan cell apoptosis cell cycle |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |