C-Nucleoside studies-15: Synthesis of 3-β-D-arabinofuranosylpyrazoles and the D-arabinofuranosyl analogue of formycin |
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Authors: | J.G. Buchanan Duncan Smith Richard H. Wightman |
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Affiliation: | Chemistry Department, Heriot-Watt University, Riccarton, Currie, Edinburgh EH14 4AS, Scotland |
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Abstract: | A synthesis of 7-amino-3-(β -D-arabinofuranosyl)pyrazolo[4 3-d]pyrimidine (13), the D-arabino analogue of formycin (1), from D-mannose is described. 1-(2,4-Dinitrophenyl)-3-(penta-O-acetyl-D-manno-pentahydroxypentyl)pyrazole was converted into the 4-nitro-derivative 18 in 90% yield using trifluoroacetyl nitrate. In four steps 18 was transformed into the 3-β-D-arabinofuranosylpyrazole 12 which gave the N-nitro derivative 24 in two further stages. Cine-substitution of the N-nitro group in 24 by cyanide ion was followed by elaboration of the pyrimidine ring to give 13. All the reactions proceeded with complete regio and stereoselectivity. |
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