Proton and carbon nuclear magnetic resonance study on some n- and o-acyl derivatives of monohydroxypyridines |
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Authors: | MR Del Giudice G Settimj M Delfini |
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Institution: | Istituto Superiore di Sanitá, Laboratorio di Chimica del Farmaco Viale Regina Elena 299, 00161 Roma Italy;Istituto di Chimica e Tecnologia dei Radioelementi, CNR, Padova Italy |
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Abstract: | Comparative study on the proton and carbon NMR spectra for a series of - and -acyl substituted monohydroxypyridines (C5H4NO: =-H, -CHO, -COCH3, -COC(CH3)3, -COCF3, -COC6H5, -SO2CH3, -SO2C6H4CH3 is reported. p]Characteristic 1H, 13 NMR and IR spectral features allow simple and unambiguous distinction between the isomeric - and/or -acyl-derivatives of 2-, 3- and 4-hydroxypyridines, so that both forms can clearly be identified when tautomeric equilibria occur, since the tautomerism rate is slow on the NMR time scale |
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