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Overview on the synthetic routes to nicotine nitriles
Authors:M. A. Salem  M. H. Helel  M. A. Gouda  Y. A. Ammar  M. S. A. El-Gaby
Affiliation:1. Department of Chemistry, Faculty of Science and Arts, King Khalid University, Mohail Assir, KSA;2. Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt;3. Department of Chemistry, Faculty of Arts and Science, Northern Border University, Rafha, KSA;4. Department of Chemistry, Faculty of Science and Arts, Taibah University, Ulla, KSA;5. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt;6. Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt;7. Department of Chemistry, Faculty of Science, Al-Azhar University, Assiut, Egypt
Abstract:The biological and medicinal properties of nicotinonitrile and its analogues have prompted enormous research aimed at developing synthetic routes to these heterocyclic. This review highlights the different synthetic routes to nicotine nitriles.
Keywords:Chalcone  enaminone  enaminonitriles  Micheal addition  nicotinonitrile
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