| 茄呢基氮芥衍生物的合成及生理活性 |
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| 引用本文： | 赵瑾,卜站伟,刘洋,王超杰.茄呢基氮芥衍生物的合成及生理活性[J].应用化学,2006,23(5):514-0. |
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| 作者姓名： | 赵瑾 卜站伟 刘洋 王超杰 |
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| 作者单位： | 河南大学化学化工学院 |
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| 基金项目： | 河南省科技厅科技攻关项目;河南大学校科研和教改项目 |
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| 摘 要： | 茄呢基氮芥衍生物的合成及生理活性;氮芥;茄呢醇;合成;生理活性
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| 关 键 词： | 茄呢基氮芥衍生物的合成及生理活性 氮芥 茄呢醇 合成 生理活性 |
| 文章编号： | 1000-0518(2006)05-0514-05 |
| 收稿时间： | 07 3 2005 12:00AM |
| 修稿时间： | 11 15 2005 12:00AM |
Synthesis and Biological Activity of New Solanesyl Nitrogen Mustards |
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| ZHAO Jin,BU Zhan-Wei,Liu Yang,WANG Chao-Jie.Synthesis and Biological Activity of New Solanesyl Nitrogen Mustards[J].Chinese Journal of Applied Chemistry,2006,23(5):514-0. |
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| Authors: | ZHAO Jin BU Zhan-Wei Liu Yang WANG Chao-Jie |
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| Institution: | College of Chemistry and Chemical Engineering, Henan University,Kaifeng 475001 |
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| Abstract: | Four solanesyl nitrogen mustards were designed and synthesized with solanesol or solanesyl amine as the carrier,maleic acid and phthalic acid as the linkers,and nitrogen mustard as the pharmacophore.Four similar nitrogen mustard derivatives were also prepared with the linear aliphatic alcohols instead of solanesyl derivatives as the carrier to compare their difference.The structures of the compounds were confirmed by IR,~(1)H NMR,MS and elemental analysis.The in vitro anti-tumor activities of these compounds were tested preliminarily on KB,Bel-7402,HCT-8,A549 and MDA cells.The data show that the nitrogen mustard with solanesol as the carrier and maleic acid as the linker inhibits all the five tested cells. |
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| Keywords: | nitrogen mustard solanesol synthesis biological activity |
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