A novel synthesis of 2,5-di-substituted pyridine derivatives by the ring opening and closing cascade (ROCC) mechanism |
| |
| Institution: | 1. Chemistry Services, GVK Biosciences Pvt. Ltd., Survey No: 125 (part) & 126, IDA Mallapur, Hyderabad 500076, Telangana State, India;2. Department of Inorganic & Analytical Chemistry, Andhra University, Waltair Junction, Visakhapatnam, Andhra Pradesh 530003, India |
| |
| Abstract: | A new regioselective method for the synthesis of 2-aryl-5-benzoylpyridine derivatives has been developed. The reaction proceeds via ring opening and closing cascade mechanism (ROCC) of isoxazole to synthesize various functionalized pyridine derivatives. This is the first report for the preparation of 2,5-di-substituted pyridines using Fe/NH4Cl as a reducing reagent. |
| |
| Keywords: | Isoxazole 2 5-Disubstituted pyridines ROCC mechanism |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
