One-pot amide synthesis from allyl or benzyl halides and amines by Pd-catalysed carbonylation |
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| Authors: | Luigino Troisi Catia Granito Francesca Rosato Valeria Videtta |
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| Affiliation: | Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, University of Salento, via Prov.le Lecce-Monteroni, 73100 Lecce, Italy |
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| Abstract: | ![]()
Amides can be prepared from allyl or benzyl halides and primary or secondary amines, using Pd(0) catalyst under CO pressure, in a one-pot synthesis. The reaction proceeds through the acyl palladium halide formation which undergoes an acylic nucleophilic substitution from the amine. |
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| Keywords: | Amides Halides Amines Palladium-catalysed carbonylation |
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