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Efficient and library-friendly synthesis of furo- and thieno[2,3-d] pyrimidin-4-amine derivatives by microwave irradiation |
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| Authors: | Ying Han Katalin Ebinger Jennifer W. Maloney Harold N. Weller |
| Affiliation: | a Bristol-Myers Squibb Company R&D, 5 Research Parkway, Wallingford, CT 06492, United States b Bristol-Myers Squibb Company R&D, Route 206 and Provinceline Road, Princeton, NJ 08543, United States |
| Abstract: | A new, divergent, efficient, and selective synthesis of furo- and thieno[2,3-d]pyrimidin-4-amine derivatives by microwave irradiation has been developed starting from readily available amines and substituted 2-aminofuran-3-carbonitrile or 2-aminothiophene-3-carbonitrile, which are converted into corresponding formamidines in DMF using benzenesulfonyl chloride. |
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