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Comparative toxicity of [3]ferrocenophane and ferrocene moieties on breast cancer cells |
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| Authors: | Meral Gormen Pascal Pigeon Marie-Aude Plamont Anne Vessières |
| Institution: | a Chimie ParisTech (Ecole Nationale Supérieure de Chimie de Paris), Laboratoire Charles Friedel, UMR CNRS 7223, 11 rue P. et M. Curie, 75231 Paris cedex 05, France b Department of Organic Chemistry, University of ?ód?, Narutowicza 68, 90-136 ?ód?, Poland |
| Abstract: | Recent results suggest that 3]ferrocenophane may be an interesting motif in the development of cytotoxic anti-cancer agents. We here report the synthesis of three such compounds based on the 1-(p-R-phenyl)-phenyl-methylidenyl)]-3]ferrocenophane skeleton with R = OH, NH2 and NHC(O)CH3 substitution on one of the phenyl rings. Cytotoxicity studies show that these compounds are up to four times more powerful against hormone-independent breast cancer cells than their corresponding ferrocene analogs. |
| Keywords: | Ferrocenophane Breast cancer Bioorganometallic Cytotoxicity |
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