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Facile transformation of glutamic acid into proline residue inside a tripeptide backbone |
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| Authors: | Adriano Mollica Federica Feliciani Ivana Cacciatore Gino Lucente |
| Institution: | a Dipartimento di Scienze del Farmaco, Università di Chieti-Pescara ‘G. d’Annunzio’, Via dei Vestini 31, 66100 Chieti, Italy b Dipartimento di Chimica e Tecnologie del Farmaco, ‘Sapienza’, Università di Roma, P.le A. Moro 5, 00185 Roma, Italy |
| Abstract: | In this Letter we present a simple reaction pathway which allows the conversion of the glutamic acid residue of a tripeptide into a proline residue. The reaction was performed by using Boc-Val-Glu-Phe-NH2 as a starting material and is based on a NaH-induced intraresidue alkylation under reaction conditions analogous to that adopted during the Freidinger lactams formation. |
| Keywords: | δ-Lactam-constrained peptides Glutamic acid Peptides Proline |
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