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A biomimetic approach to the synthesis of a mycolic acid motif |
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| Authors: | Cathryn HS Driver Gianna Toschi Mark S Baird |
| Institution: | a Department of Chemistry, University of Pretoria, Pretoria 0002, South Africa b Department of Biochemistry, University of Pretoria, Pretoria 0002, South Africa c Department of Chemistry, University of Wales, Bangor, Gwynedd LL57 2UW, UK |
| Abstract: | A new method for the stereoselective synthesis of the (R,R)-β-hydroxy-α-alkyl fatty acid fragment of mycolic acids, via an asymmetric anti-aldol reaction is reported. The ‘mycolic acid motif’ fragment was prepared in three steps and >98% ee. |
| Keywords: | Tuberculosis Mycolic acid Mycolic acid motif Asymmetric anti-aldol reaction |
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