One-pot derivatization of medicinally important 9-aminoacridines by reductive amination and SNAr reaction |
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| Authors: | Gary Gellerman Vladimir Gaisin Tamara Brider |
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| Affiliation: | Department of Biological Chemistry, Ariel University Center of Samaria, PO Box 3, Ariel 40700, Israel |
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| Abstract: | A new highly efficient one-pot derivatization of medicinally important 9-aminoacridines (9-AA) at the amine position is described. Simple reductive amination and SNAr reaction using easily accessible starting materials give a fast entry to novel 9-AA derivatives for biological screening. |
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| Keywords: | 9-Aminoacridine Reductive alkylation Nucleophilic substitution One-pot synthesis |
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