Unique substituted 3-oxo-1,2,3,4-tetrahydropyrazino[1,2-a]benzimidazole-1-carboxamides generated by Ugi 3CC using bifunctional starting material |
| |
| Authors: | Mehdi Ghandi Nahid Zarezadeh Abuzar Taheri |
| |
| Institution: | School of Chemistry, College of Science, University of Tehran, Tehran, PO Box 14155 6455, Iran |
| |
| Abstract: | 2-(2-Formyl-1H-benzimidazol-1-yl)acetic acid, as a bifunctional formyl-acid was prepared in four steps. This compound underwent one-pot reaction with primary amines, and alkyl isocyanides under Ugi conditions. A series of novel 3-oxo-1,2,3,4-tetrahydropyrazino1,2-a]benzimidazole-1-carboxamides were obtained in moderate to excellent yields. |
| |
| Keywords: | Ugi reaction 6-Oxo-pyrazine-2-carboxamides Multicomponent reactions |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
