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A novel, one-pot, solvent-, and catalyst-free synthesis of 2-aryl/alkyl-4(3H)-quinazolinones
Authors:Mehdi Adib  Samira Ansari  Hamid Reza Bijanzadeh
Institution:a School of Chemistry, University College of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran
b Department of Chemistry, Tarbiat Modarres University, PO Box 14115-175, Tehran, Iran
Abstract:A novel and one-pot synthesis of 2-aryl/alkyl-4(3H)-quinazolinones is described. The in situ prepared amidoximes from the reaction between nitriles and hydroxylamine are condensed with anthranilic acids under solvent- and catalyst-free conditions to produce the title compounds in excellent yields.
Keywords:Anthranilic acids  Nitriles  Amidoximes  2-Aryl/alkyl-4(3H)-quinazolinones  Solvent-free  Catalyst-free
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