Synthesis of dialkyl 5-(aryl)-1-phenyl-1H-prazole-3,4-dicarboxylates via a one-pot and four-component reaction |
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| Authors: | Abdolali Alizadeh Tahereh Firuzyar |
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| Institution: | a Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran, Iranb Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China |
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| Abstract: | A number of new dialkyl 5-(aryl)-1-phenyl-1H-prazole-3,4-dicarboxylate derivatives have been prepared regiospecifically in moderate to good yield from the cyclocondensation reaction of dialkyl (E)-2-(dialkoxyphosphoryl)-3-(aroyl)-2-butenedioate, derived from the reaction between trimethyl phosphite, an acetylenic ester, and an aroyl chloride, with phenylhydrazine. The reaction is four-component and is carried out under reflux conditions in dry toluene. |
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| Keywords: | Trimethyl phosphite Acetylenic ester Aroyl chlorides Phenylhydrazine Pyrazole Four-component reaction |
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