海绵Phacelliafusca中含氮化合物的分离与结构鉴定

从采自中国南海西沙群岛海域的海绵Phacellia fusca Schmidt中得到4个含氮 化合物。经~1H NMR,~(13)C NMR,HMQC,HMBC,~1H-~1HCOSY,FABMS和EIMS等光谱分析 ，确证其结构分别为：N,N'-二2-乙氧基-1（Z）-乙烯基]脲（1），2- Bromoaldisin(2),Aldisin(3)Dibromophakellin盐酸盐(4)。其中化合物1为一具有 对称结构的新脲类化合物，命名Phacelliaurea A；化合物4是首次从该海绵中分离 得到的已知胍基生物碱，首次报到了它的~(13)C NMR数据及其归属。

Four Compounds Containning Nitrogen from Marine Sponge Phacellia fusca Schmidt

Four compounds containning nitrogen have been isolated from the sponge Phacellia fusca Schmidt, collected from the Xisha Islands in the South China Sea. The structures of these compounds were characterized by ~1H NMR, ~(13)CNMR, HMQC, HMBC, ~1H-~1HCOSY, FABMS and EIMS as N, JV'-bis2-ethoxyl-l(Z)-vinyl] urea (1), 2-bromoaldisin (2), aldisin (3) and dibromophakellin (4). Among them, compound 1 is a new urea, containing a symmetrical partial structure, named as phacelliaurea A. Compound 4 is a known guam'dine alkaloid, first isolated from the sponge Phacellia fusca Schmidt, and the data and assignments of its ~(13)C NMR was first reported.