Synthesis of some new biologically active coumarin derivatives

The reaction of 4-hydroxycoumarin in toluene with a variety of aromatic binucleophilic compounds has been studied. 3-(Dimethylaminomethylene)chromane-2,4-dione was used as a key intermediate for the preparation of bis[N-(4-oxocoumarinylmethylene)]-1,4-diamines. Alternative synthetic procedures and antibacterial activity data of some of the new compounds are given. Published in Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 361–366, March, 2006.