Novel route for the synthesis of structurally diverse pyrrolo[2,1-a]isoquinoline in aqueous micellar medium |
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Authors: | Subhendu NaskarMaitreyee Banerjee Abhijit HazraShyamal Mondal Arindam MaityRupankar Paira Krishnendu B. SahuPritam Saha Sukdeb BanerjeeNirup B. Mondal |
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Affiliation: | Department of Chemistry, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, 4 Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, India |
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Abstract: | A high yielding environmentally benign protocol has been developed for the synthesis of pyrrolo[2,1-a]isoquinoline using chromone-3-carboxaldehyde, isoquinoline and phenacyl bromide/bromoacetic acid ester as reagents in aqueous micellar medium. The method is operationally simple and more effective compared to the previous methods in terms of the yield of the products as well as the reaction time. |
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Keywords: | Pyrrolo[2,1-a]isoquinoline Micelle Chromone-3-carboxaldehyde 1,3-Dipolar cycloaddition reaction Reactions in water |
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