| 丙烯酸β-羧乙酯-苯乙烯共聚物缩合异烟肼的合成及其水解释放研究 |
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| 引用本文： | 陈星,胡力平,焦书科.丙烯酸β-羧乙酯-苯乙烯共聚物缩合异烟肼的合成及其水解释放研究[J].高分子学报,1988,0(5):385-388. |
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| 作者姓名： | 陈星 胡力平 焦书科 |
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| 作者单位： | 北京化工学院应用化学系 北京
(陈星，胡力平)，北京化工学院应用化学系 北京(焦书科) |
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| 摘 要： | <正> 大分子载体药物是精细高分子合成的一个重要研究领域,作为药物载体的大分子骨架需有良好的生物相容性及控制释放能力。本文采用具有较长柔性侧支链的丙烯酸β-羧乙酯(APA)-苯乙烯(St)共聚物作载体,并通过羧基与抗结核药物异烟肼反应,制备出毒性较低并能控制释放的大分子载体异烟肼药物。
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| 关 键 词： | 丙烯酸β-羧乙酯 大分子酰胺(异烟肼) 中性-酸性水解释放 |
| 收稿时间： | 1987-09-06 |
THE STUDIES ON SYNTHESIS OF CONDENSATION PRODUCT OF ACRYLOXYPROPIONIC ACID-STYRENE COPOLYMER AND ISONIAZIDUM AND ITS BEHAVIOR DURING THE PROCESS OF HYDROLYSIS |
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| CHEN Xing,HU Li-ping,JIAO Shu-ke.THE STUDIES ON SYNTHESIS OF CONDENSATION PRODUCT OF ACRYLOXYPROPIONIC ACID-STYRENE COPOLYMER AND ISONIAZIDUM AND ITS BEHAVIOR DURING THE PROCESS OF HYDROLYSIS[J].Acta Polymerica Sinica,1988,0(5):385-388. |
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| Authors: | CHEN Xing HU Li-ping JIAO Shu-ke |
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| Institution: | Department of Applied Chemistry; Beijing Institute of Chemical Technology; Beijing |
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| Abstract: | The synthesis of macromolecular-drug and its behavior during the process of hydrolysis at the temperature near that of human body were studied. β-acryloxypropionic acid-styrene copolymer was used as drug carrier and it reacted with the isoniazidum drug through ma-cromolecular reaction. The IR analysis of products demonstrated that the conversion of car-oxylic group could reach 61%. The results of neutral or acidic hydrolysis of P(St-co-APA) attaching isoniazidum showed that the hydrolysis of the macromolecular-drug could be controlled due to the particular structure of acryloxypropionic acid unit. |
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| Keywords: | β-acryloxypropionic acid Macromolecular amide (isoniazidum) Neu- tral-acidic hydrolysis |
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