Cytotoxic diterpenoids from Podocarpus madagascariensis from the Madagascar rainforest |
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| Authors: | Reynolds Micah Chaturvedula V S Prakash Ratovoson Fidisoa Andriantsiferana Rabodo Rasamison Vincent E Guza Rebecca C Kingston David G I |
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| Institution: | Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0212, USA. |
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| Abstract: | Bioassay-directed fractionation of an extract of the root and bark of Podocarpus madagascariensis resulted in the isolation of a new totarol diterpenoid (1) in addition to the three known cytotoxic diterpenoids 19-hydroxytotarol (2), totaradiol (3), and 4beta-carboxy-19-nor-totarol (4). The structure of the new compound 1 was established as methyl-13-hydroxy-14-isopropyl-9(11),12,14(8)-podocarpatriene-19-oate on the basis of 1D and 2D NMR spectroscopic interpretation and methylation of 4. All the compounds exhibited cytotoxic activity against the A2780 ovarian cancer cell line. |
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