| Asymmetric hydrogenation of aromatic ketones using new chiral-bridged diphosphine/diamine-Ru(Ⅱ) complexes |
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| 作者姓名： | Yu Ming Cui Lai Lai Wang Fuk Yee Kwong Wei Sun |
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| 作者单位： | a State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China;b Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical technology, The Hong Kong Polytechnic University, Hong Kong, China;c Graduate University of Chinese Academy of Sciences, Beijing 100039, China |
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| 基金项目： | We thank the National Natural Science Foundation of China (Nos.20343005,20473107,20673130,and 20773147) and the Hong Kong PolyU Joint Supervision Scheme (A-PH78) for financial support. |
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| 摘 要： | <正>A series of chiral secondary alcohols were easily prepared by means of asymmetric hydrogenation of prochiral aromatic ketones using a new((R_(ax))-BuP)/(R,R)-DPEN-Ru(Ⅱ) complex catalyst system.The hydrogenation of 2-methylacetophenone in n-butanol (t-BuOK/Ru =45.6/1,S/C = 500,20 atm.of H_2,20℃,48 h) afforded(S)-1-(2'-methylphenyl)ethanol in 92%ee and99% conversion.
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| 收稿时间： | 30 March 2010 |
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