Quinolin-2(1H)-one-triazole derived Schiff bases and their Cu(II) and Zn(II) complexes: Possible new therapeutic agents |
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| Authors: | Bernadette S Creaven Michael Devereux Agnieszka Foltyn Siobhán McClean Georgina Rosair Venkat Reddy Thangella Maureen Walsh |
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| Institution: | 1. Department of Science, Institute of Technology Tallaght, Dublin 24, Ireland;2. Centre for Applied Science and Health, Institute of Technology Tallaght, Dublin 24, Ireland;3. The Inorganic Pharmaceutical and Biomimetic Research Group, Focas Institute, Dublin Institute of Technology, Kevin St., Dublin 2, Ireland;4. Chemistry, School of Engineering and Physical Science, Heriot Watt University, UK |
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| Abstract: | The condensation of 4-amino-1,2,4-triazole with N-substituted-3-formyl-4-hydroxyquinolin-2-(1H)-one derivatives has lead to the synthesis of a new series of quinolin-2(1H)-one-triazole derived Schiff base ligands (1–3). Cu(II) and Zn(II) complexes (1a–3a and 1b–3b, respectively) of these ligands were also prepared. The complexes were characterised by standard techniques and for two of the complexes X-ray crystallography confirmed that the geometry at the metal centre was octahedral in both cases and that the Schiff base acted as a bidentate ligand coordinating to the metal(II) ion through the deprotonated oxygen and azomethine nitrogen atoms. All of the compounds were investigated for their antimicrobial activities against a fungal strain, Candida albicans, and against Gram-positive and Gram-negative bacteria. The compounds were found to be active against C. albicans but inactive against Staphylococcusaureus and Escherichia coli. |
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| Keywords: | Quinolin-2(1H)-one 4-Amino-1 2 4-triazole Schiff bases Metal(II) complexes Biological activity X-ray structures |
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