Novel bioactive vic-dioxime ligand containing piperazine moiety: Synthesis,X-ray crystallographic studies, 2D NMR applications and complexation with Ni(II) |
| |
| Authors: | Aytek Yılmaz,Bilge Taner,Pervin Deveci,Aslıhan Yılmaz Obalı,Uğur Arslan,Ertan Şahin,H. İsmet Uç an,Emine Ö zcan |
| |
| Affiliation: | 1. Selcuk University, Faculty of Science, Department of Chemistry, Konya, Turkey;2. Selcuk University, Selcuklu Medical Faculty, Department of Clinical Microbiology, Konya, Turkey;3. Atatürk University, Faculty of Arts and Sciences, Department of Chemistry, Erzurum, Turkey |
| |
| Abstract: | ![]()
A new vic-dioxime ligand bearing an important pharmacophore substituent, anti-1-(4-benzylpiperazine-1-yl) phenylglyoxime (LH2) (Scheme 1), has been synthesized and its nickel(II) complex was obtained by the reaction of NiCl2·6H2O and the ligand. The characterization of the newly formed compounds was performed by elemental analysis, FT-IR, 1D NMR (1H, 13C, DEPT), 2D NMR (HMBC), ESI mass-spectrometry, TG/DTA, X-ray crystallography. The antibacterial activity was also studied against Staphylococcus aureus ATCC 25923, Streptococcus mutans RSHM 676, Enterococcus faecalis ATCC 29212, Lactobacillus acidophilus RSHM 06029, Escherichia coli ATCC 25922, E. coli ATCC 35218, Pseudomonasaeruginosa ATCC 27853. The antimicrobial test results indicated that all the compounds have mild antibacterial activity against both Gram negative and Gram positive bacterial species. |
| |
| Keywords: | vic-Dioxime Nickel(II) complexes Piperazine moiety 1D and 2D NMR Crystal structure Antimicrobial activity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
