Syntheses and characterization of Cu,Ni and Zn binding capability of histidinehydroxamic acid derivatives |
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| Authors: | Edit Csapó ,Pé ter Buglyó ,Nó ra Veronika Nagy,M. Amé lia Santos,Alma Corona,Etelka Farkas |
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| Affiliation: | 1. Department of Inorganic and Analytical Chemistry, University of Debrecen, H-4010 Debrecen, Hungary;2. Institute of Structural Chemistry, Chemical Research Center of the Hungarian Academy of Sciences, H-1525 P.O. Box 17, Budapest, Hungary;3. Centro de Química Estrutural, Instituto Superior Técnico, 1049-001 Lisboa, Portugal;4. Universidad de Guanajuato, Facultad de Quimica, Guanajuato, GTO. 36050, Mexico |
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| Abstract: | Two histidinehydroxamic acid derivatives (N-methyl-histidinehydroxamic acid, N-Me-Hisha and Z-histidinehydroxamic acid, Z-Hisha) have been synthesized and their complexation with Cu2+-, Ni2+- and Zn2+-ions has been studied by using pH-potentiometric, UV–Vis, CD, 1H NMR, EPR and ESI-MS methods. Both of the two new derivatives contain one donor atom less compared to the histidinehydroxamic acid (Hisha). In the case of N-Me-Hisha the hydroxamate-N as donor is eliminated, while the coordination of the amino-N of Z-Hisha is not possible at all. |
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| Keywords: | Histidinehydroxamic acid derivatives Cu2+-, Ni2+-, Zn2+-complexes Solution equilibrium Potential metalloenzyme inhibitors |
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