| Synthesis and Crystal Structure of N-methyl- 9- （4-bromophenyl）-1,2,3,4,5,6,7,8,9,10- decahydroacridine- 1,8-dione under Microwave Irradiation |
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| 引用本文： | HUA Guo-Pinga ZHANG Xiao-Jingb TU Shu-Jiangb② ZHU Song-Leib LI Tuan-Jieb ZHU Xiao-Tongb ZHANG Jin-Pengb a(Xuzhou Institute of Architectural Technology,Xuzhou,Jiangsu 221008,China) b (Department of Chemistry,Xuzhou Normal University,Key Laboratory of Biotechnology on Medical Plant,Xuzhou,Jiangsu 221116,China). Synthesis and Crystal Structure of N-methyl- 9- （4-bromophenyl）-1,2,3,4,5,6,7,8,9,10- decahydroacridine- 1,8-dione under Microwave Irradiation[J]. 结构化学, 2005, 24(4): 399-402 |
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| 作者姓名： | HUA Guo-Pinga ZHANG Xiao-Jingb TU Shu-Jiangb② ZHU Song-Leib LI Tuan-Jieb ZHU Xiao-Tongb ZHANG Jin-Pengb a(Xuzhou Institute of Architectural Technology Xuzhou Jiangsu 221008 China) b (Department of Chemistry Xuzhou Normal University Key Laboratory of Biotechnology on Medical Plant Xuzhou Jiangsu 221116 China) |
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| 作者单位： | HUA Guo-Pinga ZHANG Xiao-Jingb TU Shu-Jiangb② ZHU Song-Leib LI Tuan-Jieb ZHU Xiao-Tongb ZHANG Jin-Pengb a(Xuzhou Institute of Architectural Technology，Xuzhou，Jiangsu 221008，China) b (Department of Chemistry，Xuzhou Normal University，Key Laboratory of Biotechnology on Medical Plant，Xuzhou，Jiangsu 221116，China) |
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| 基金项目： | This work was supported by the National Natural Science Foundation of China (No. 20372057)，Natural Science Foundation of Jiangsu Province (No. BK2001142)，the Suzhou University Organic Synthesis Open Laboratory of Jiangsu Province (No. S81091 11) and the Key Lab of Biotechnology for Medicinal Plants of Jiangsu Province (No. 01AXL 14) |
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| 摘 要： | 1 INTRODUCTION Since the discovery of pharmacological effectsof 1,4-dihydropyridine (1,4-DHPs) as calcium mo-dulators[1], a great deal of work has been directedtowards the synthesis of 1,4-DHPs acting as cal-cium antagonists[2]. The chemical modifications onthe DHP ring, such as the introduction of differentsubstituents on heteroatoms[3], have allowed theexpansion of researches on structure-activity rela-tionship to have new insight into the molecularinteractions at the receptor l…
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| 关 键 词： | 晶体结构 合成方法 N-甲基-9-（4-溴苯）-1,2,3,4,5,6,7,8,9,10-十氢吖啶-1,8-酮 微波辐射法 |
Synthesis and Crystal Structure of N-methyl-9-(4-bromophenyl)-1,2,3,4,5,6,7,8,9,10- decahydroacridine-1,8-dione under Microwave Irradiation |
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| HUA Guo-ping,ZHANG Xiao-jing,TU Shu-Jiang,ZHU Song-Lei,LI Tuan-Jie,ZHU Xiao-tong,ZHANG Jin-Peng. Synthesis and Crystal Structure of N-methyl-9-(4-bromophenyl)-1,2,3,4,5,6,7,8,9,10- decahydroacridine-1,8-dione under Microwave Irradiation[J]. Chinese Journal of Structural Chemistry, 2005, 24(4): 399-402 |
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| Authors: | HUA Guo-ping ZHANG Xiao-jing TU Shu-Jiang ZHU Song-Lei LI Tuan-Jie ZHU Xiao-tong ZHANG Jin-Peng |
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| Abstract: | The crystal structure N-methyl-9-(4-bromophenyl)-1,8-dioxo-1,2,3,4,5,6,7,8,9,10- decahydroacridine(C20H20BrNO2) was determined by single-crystal X-ray diffraction analysis. It belongs to P21/n space group, with a = 10.7999(18), b = 13.845(3), c = 11.4031(3) (A), β = 99.324(4)°, Dc = 1.525 g/cm3, Z = 4, λ = 0.71070(A), μ(MoKα = 2.455 mm-1, Mr = 386.28, V = 1682.5(5) (A)3, F(000) = 792, the final R = 0.0463 and wR = 0.1053. In the crystal structure, the pyridine ring adopts a boat conformation, the two six-numbered rings fused with pyridine ring adopt twisting boat con- formation. |
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| Keywords: | acridine synthesis microwave irradiation crystal structure |
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