Second-generation total synthesis of haterumalide NA using B-alkyl Suzuki-Miyaura coupling |
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| Authors: | Hayakawa Ichiro Ueda Mitsuru Yamaura Masashi Ikeda Yoichi Suzuki Yuta Yoshizato Kensaku Kigoshi Hideo |
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| Affiliation: | Department of Chemistry, Graduate School of Pure and Applied Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan. |
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| Abstract: | ![]()
Second-generation total synthesis of haterumalide NA, a potent cytotoxic marine macrolide, was achieved by using B-alkyl Suzuki-Miyaura coupling and Nozaki-Hiyama-Kishi coupling as key steps (1.2% in 33 steps). Compared to our first-generation approach, the second-generation synthesis is much improved in the yield of key intermediate. |
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