Direct asymmetric aldol-Tishchenko reaction of aliphatic ketones catalyzed by syn-aminoalcohol-Yb(III) complexes |
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| Authors: | Mlynarski Jacek Jankowska Joanna Rakiel Bartosz |
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| Institution: | Institute of Organic Chemistry, Polish Academy of Sciences, Warsaw. mlynar@icho.edu.pl |
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| Abstract: | The asymmetric direct aldol condensation of aldehydes with ethyl- and propylketones is catalyzed by syn-alpha-aminoalcohol-Yb(OTf)3 complexes, yielding the anti-1,3-diol monoesters with high diastereocontrol and good enantioselectivity. Three adjacent stereogenic centers are created in a simultaneous aldol condensation and Evans-Tishchenko reduction in an acyclic system. |
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