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| 含哌啶取代酞菁金属配合物的合成及其对癌细胞光灭活作用 | |
| 引用本文： | 黄紫洋,薛金萍,陈锦灿,陈耐生,黄金陵.含哌啶取代酞菁金属配合物的合成及其对癌细胞光灭活作用[J].高等学校化学学报,2008,29(3):445-448. |
| 作者姓名： | 黄紫洋 薛金萍 陈锦灿 陈耐生 黄金陵 |
| 作者单位： | 1. 福州大学功能材料研究所,福州,350002;福建师范大学化学与材料学院,福州,350007 2. 福州大学功能材料研究所,福州,350002 3. 中国科学院福建物质结构研究所,福州,350002 |
| 基金项目： | 福建省科技厅科研项目 , 福建省自然科学基金 |
| 摘 要： | 采用“模板法”合成8种含哌啶取代酞菁金属配合物(PEO)4PcM, M=Zn, Ni, Co, Cu, PEO=2-(哌啶-1-基)乙氧基], 采用FTIR、质谱和元素分析等技术对其进行了表征. 分别测定了它们的紫外-可见吸收光谱、荧光发射光谱和光敏化产生单线态氧的能力. 研究结果表明, 2种酞菁锌配合物均具有较高的摩尔消光系数、一定的荧光量子产率和较大的单线态氧生成速率. 通过光动力灭活BEL7402肝癌细胞的试验研究发现, β-(PEO)4PcZn的浓度为10 μmol/L时, 在670 nm激光辐照下, 光剂量为1.2 J时, 对癌细胞的抑制率可达到83%. |
| 关 键 词： | 酞菁金属配合物 N-哌啶乙醇 合成 光灭活作用 |
| 文章编号： | 0251-0790（2008）03-0445-04 |
| 收稿时间： | 2007-08-20 |
| 修稿时间： | 2007年8月20日 |
Synthesis of Metal Phthalocyanines Containing Piperidine and Their Photoinhibition on Cancer Cell |
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| HUANG Zi-Yang,XUE Jin-Ping,CHEN Jin-Can,CHEN Nai-Sheng,HUANG Jin-Ling.Synthesis of Metal Phthalocyanines Containing Piperidine and Their Photoinhibition on Cancer Cell[J].Chemical Research In Chinese Universities,2008,29(3):445-448. | |
| Authors: | HUANG Zi-Yang XUE Jin-Ping CHEN Jin-Can CHEN Nai-Sheng HUANG Jin-Ling |
| Institution: | Institute on Research of Functional Materials, Fuzhou University, Fuzhou 350002, China;;College of Chemistry and Materials Science, Fujian Normal University, Fuzhou 350007, China;;Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China |
| Abstract: | “The template approach” was used for the synthesis of eight metal phthalocyanine complexes containing piperidine group(PEO)4PcM, where M=Zn, Ni, Co, Cu, PEO=2-(piperidin-1-yl) ethyoxyl. These complexes were characterized by FTIR, mass spectrum, elemental analysis and so on. The UV-Vis absorption spectra, fluorescence emission spectra and capacity of photo-generating singlet oxygen were examined. The results showed that two zinc phthalocyanine complexes possessed high molar extinction coefficient, fluorescence quantum yield, high rate of photo-generating singlet oxygen. The complex with formula β-(PEO)4PcZn had a photoinhibition effect to BEL7402 liver cancer cells up to 83% in case that the irradiation with 670 nm laser light(dosage 1.2 J) and the concentration of β-(PEO)4PcZn with 10 μmol/L were used. |
| Keywords: | Metal phthalocyanine N-Piperidineethanol Synthesis Photoinhibition |
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