| 高效液相色谱法测定硝苯地平片含量及其含量均匀度 |
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| 引用本文： | 邢玉仁,王杰.高效液相色谱法测定硝苯地平片含量及其含量均匀度[J].色谱,1999,17(3):308-309. |
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| 作者姓名： | 邢玉仁 王杰 |
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| 作者单位： | [1]山东医药工业研究所 [2]山东省药品检验所 |
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| 摘 要： | 采用高效液相色谱法测定了硝苯地平片含量及其含量均匀度。色谱柱为C18柱，流动相为V（甲醇）：V（三乙胺缓冲液，pH5．20）=68:32，紫外检测器，检测波长为237um。在此色谱条件下可得到较宽的线性范围和较高的回收率，其分解产物亦可得到良好的分离。
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| 关 键 词： | 高效液相色谱法 硝苯地平片 均匀度 |
Determination of nifedipine content and its uniformity in tablets by high performance liquid chromatography] |
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| Y Xing,J Wang.Determination of nifedipine content and its uniformity in tablets by high performance liquid chromatography][J].Chinese Journal of Chromatography,1999,17(3):308-309. |
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| Authors: | Y Xing J Wang |
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| Institution: | Shandong Institute of Pharmaceutical Industry, Jinan, 250100. |
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| Abstract: | An HPLC method with diazepam as internal standard was developed to determine nifedipine content and its uniformity in tablets. The analytical column was a C18 column, the mobile phase consisted of V (methanol):V(triethylamine, pH 5.20) = 68:32. The detection was carried out with UV detector (lambda = 237 nm). Under this condition, the linear range was wide(8-80 mg/L) and the recovery was high (99.86%). The proposed method is simple and accurate and the decomposed product can be separated as well. Therefore, the quality of nifedipine tablets can be effectively controlled. |
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| Keywords: | NULL |
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