Thermal characterization of indinavir sulfate using TG,DSC and DSC-photovisual |
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| Authors: | Rosali Maria Ferreira da Silva Flávia Patrícia Morais de Medeiros T G Nascimento R O Macêdo P J R Neto |
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| Institution: | 1.Laboratório de Tecnologia dos Medicamentos - Departamento de Ciências Farmacêuticas,Universidade Federal de Pernambuco,Pernambuco,Brazil;2.Laboratório de Controle de Qualidade de Fármacos e Medicamentos - Escola de Enfermagem e Farmácia,Universidade Federal de Alagoas - UFAL,Alagoas,Brazil;3.Laboratórios Unificados de Desenvolvimento de Medicamentos e Ensaios - Departamento de Ciências Farmacêuticas,Universidade Federal da Paraíba - UFPB,Jo?o Pessoa - PB,Brazil;4.Laboratório Farmacêutico do Estado de Pernambuco - LAFEPE,Pernambuco,Brazil |
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| Abstract: | The object of the present work is to study the thermal characteristics of indinavir sulfate and to evaluate the quality of
the raw materials. Indinavir A, B, C and reference samples were obtained from different suppliers and submitted to TG, DSC
and DSC-photovisual analyses. TG/DTG curves indicated a desolvation and dehydration processes and were confirmed by DSC. According
to the DSC curves the fusion took place at about 141–142°C for indinavir C and Reference sample B and about 146–149°C for
the others. DSC-photovisual showed insoluble raw materials for indinavir C at 160°C. Indinavir sulfate is highly hygroscopic
drug which requires attention during storage and manufacture by pharmaceutical industry. |
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