Synthesis of alpha-CF2-mannosides and their conversion to fluorinated pseudoglycopeptides |
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| Authors: | Poulain Florent Serre Anne-Lise Lalot Jérôme Leclerc Eric Quirion Jean-Charles |
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| Affiliation: | Université et INSA de Rouen, CNRS, UMR 6014 C.O.B.R.A.-IRCOF, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex, France. |
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| Abstract: | A methodology allowing the synthesis alpha-CF(2)-mannosides, based on the addition of a difluoroenoxysilane to a glycal followed by a dihydroxylation reaction, is described. The resulting 2,2-difluoro-2-mannosylacetate is converted into two pseudoglycopeptides which may act as E- and P-selectin inhibitors. |
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