Antibacterial poly(3‐hydroxybutyrate‐co‐4‐hydroxybutyrate) fibrous membranes containing quaternary ammonium salts |
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Authors: | Xiaoyan Fan Maoli Yin Zhiming Jiang Nengyu Pan Xuehong Ren Tung‐Shi Huang |
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Institution: | 1. Key Laboratory of Eco‐textiles of Ministry of Education, Jiangsu Engineering Technology Research Center for Functional Textiles, College of Textiles and Clothing, Jiangnan University, Wuxi, Jiangsu, China;2. Department of Poultry Science, Auburn University, Auburn, USA |
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Abstract: | In this study, antimicrobial membranes based on biodegradable material poly(3‐hydroxybutyrate‐co‐4‐hydroxybutyrate) P(3HB‐4HB)] and quaternary ammonium salts (QASs) by two methods have been performed. Three QASs with varied alkyl chain lengths have been synthesized successfully and characterized by 1H nuclear magnetic resonance and Fourier transform infrared. The synthesized QASs were blended with P(3HB‐4HB) and electrospun into composite fibrous membranes or casted into conventional membranes. Electrospun fibrous membranes with large surface areas are a superior type of antimicrobial biomaterials, and they exhibit preferable properties than solution casting membranes. Specifically, electrospun fibrous membranes are tougher and can inactivate both Gram‐positive Staphylococcus aureus and Gram‐negative Escherichia coli O157:H7 in a contact time of 30 min, whereas the solution casting membranes cannot. The length of alkyl chain in the quaternary ammonium groups on the modified P(3HB‐4HB) membranes is able to influence the antimicrobial activity. This type of antimicrobial material may have potential applications in biomaterial field. Copyright © 2016 John Wiley & Sons, Ltd. |
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Keywords: | antibacterial poly(3‐hydroxybutyrate‐co‐4‐hydroxybutyrate) quaternary ammonium salts electrospinning |
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