手性自负载催化剂研究新进展

催化剂的负载和回收再利用是提高其使用效率、降低反应成本和减少金属离子对产物污染的一条有效途径。与传统的负载模式不同, 手性自负载催化剂通过含双或多官能团的手性配体与金属通过自组装形成一类有机-无机聚合物，因此无需使用任何载体，即能够有效地实现手性催化剂的回收和再利用。近年来，手性自负载催化剂作为一种新的负载模式，已经成功地应用于一些非均相催化的不对称反应中。本文概述了手性自负载催化剂的在一些不对称催化反应研究中取得的新进展。

Recent Progress in Self-Supported Chiral Catalysts

The immobilization of homogeneous catalysts for recycle and reuse provides an effective way to solve the problems associated with the catalyst cost and metal contamination in a homogeneous catalytic process. Different from the conventional catalyst immobilization methods, the self-supporting strategy utilizes homochiral metal-organic coordination polymers generated by self-assembly of chiral multitopic ligands with metal ions without using any support. The self-supported chiral catalysts as a novel immobilization of homogeneous catalysts strategy demonstrated excellent enantioselectivities in heterogeneous catalysis of a variety of asymmetric reactions. This paper reviews the progress in the research on a variety of heterogeneous asymmetric catalytic reactions with self-supported chiral catalysts.Contents 
1 Introduction 
2 The concept of the “self-supporting” strategy 
3 Homochiral self-supported catalysts (type Ⅰ) in heterogeneous asymmetric ractions 
3.1 Asymmetric carbon-carbon bond-forming reactions 
3.2 Enantioselective oxidations 
3.3 Enantioselective hydrogenations 
4 Pendant auxiliaries on self-supported catalysts (Type Ⅱ) in heterogeneous asymmetric ractions 
4.1 Asymmetric carbon-carbon bond-forming reactions
4.2 Enantioselective oxidations 
4.3 Enantioselective hydrogenations 
5 Conclusions and outlook