Accelerated hydrolysis of esters catalyzed by receptors, II. Degradation of RNA by polyvinylpyrrolidone |
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| Authors: | Sung-Sik You Hyeong-Won Ryu Young Cho Dae-Young Kim and Thong-Sung Ko |
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| Institution: | (1) Department of Biochemistry, Chungnam National University, 305-764 Taejon, Republic of Korea;(2) Department of Chemistry, Soonchunhyang University, Asan 336-745, Chungnam, Republic of Korea |
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| Abstract: | The nonenzymatic hydrolysis of RNA by polyvinylpyrrolidone (PVP) has been investigated. A bell-shaped kinetics was observed
when the first order rate constant of the reaction was ploted as a function of PVP concentration, which means the kinetic
feature of PVP as a degradative receptor distinct from those of degradative enzymes (e.g., ribonuclease). |
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| Keywords: | RNA nonenzymatic catalysis PVP |
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