| New method in synthesizing an optical active intermediate for （R,R）-formoterol |
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| 作者姓名： | Wei Fan Lei Chen Li Hai Yong Wu |
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| 作者单位： | Key Laboratory of Drug Targeting Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China |
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| 基金项目： | This work was supported by the National Natural Science Foundation of China (No. 29972013). |
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| 摘 要： | （R）-1-（4-Methoxyphenyl）propan-2-amine 2a, an optical active intermediate for （R,R）-formoterol, was synthesized from Dalanine in 65% overall yield by using a simple route, which contained protecting amino group, cyclization, coupling with Grignard reagent, reduction and deprotection.
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| 关 键 词： | 4-甲氧苯基 营养药 中间体 合成方法 |
| 收稿时间： | 2007-10-23 |
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